Safe. Effective.

100% Bold.

Listerine Antiseptic has been extensively tested with over 30 long-term clinical trials

SAFE FOR BOTH DAILY AND LONG-TERM USE

  • Does not promote oral dryness1-3
  • Does not disrupt the normal balance of oral flora2,3
  • No emergence of resistant strains, even with long-term use2,3
  • Does not promote significant tooth stain or calculus (tartar) formation4-7

ALCOHOL-CONTAINING RINSES HAVE NO CAUSAL LINK TO ORAL DRYNESS

In clinical trials:

  • Safe for xerostomic patients1
  • Favorable tolerability, no drying of oral mucosa, and no decreased salivary flow rates1
  • No significant differences in salivary flow rates or patient-reported sensations of dry mouth between alcohol and non-alcohol-containing mouthrinse groups2
  • Alcohol-based essential oil mouthrinse no more likely to cause a reduction in salivary flow or perceived dryness than a non-alcohol-based cetylpyridinium chloride (CPC) mouthrinse3

ALCOHOL-CONTAINING RINSES HAVE NO CAUSAL LINK TO ORAL CANCER

In clinical trials:

  • An FDA subcommittee reviewed 7 case-control studies and concluded: “Data do not support a causal relationship between the use of alcohol-containing mouthrinses and oral cancer. The vote was unanimous…”4
  • Alcohol-containing mouthwash does not increase risk of oropharyngeal cancer5
  • Link between mouthwash use (specifically alcohol-containing mouthwash) and oral cancer is not supported by epidemiological evidence6
  • No association between use of mouthwash containing alcohol and oral cancer risk7

References: 1. Fischman SL, Aguirre A, Charles CH. Use of essential oil-containing mouthrinses by xerostomic individuals: determination of potential for oral mucosal irritation. Am J Dent. 2004;17(1):23-26. 2. Kerr AR, Katz RW, Ship JA. A comparison of the effects of 2 commercially available nonprescription mouthrinses on salivary flow rates and xerostomia. Quintessence Int. 2007;38(8):e440-447. 3. Kerr AR, Corby PM, Kalliontzi K, McGuire JA, Charles CA. Comparison of two mouthrinses in relation to salivary flow and perceived dryness. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(1):59-64. 4. Food and Drug Administration. Oral health care drug products for over-the-counter human use; antigingivitis/antiplaque drug products; establishment of a monograph; proposed rules. Part III. Federal Register. 2003;68(103):32232-32287. 5. Cole P, Rodu B, Mathisen A. Alcohol-containing mouthwash and oropharyngeal cancer: a review of the epidemiology. J Am Dent Assoc. 2003;134(8):1079-1087. 6. La Vecchia C. Mouthwash and oral cancer risk: an update. Oral Oncol. 2009;45(3):198-200. 7. Boyle P, Gandini S, Boffetta P, Negri E, La Vecchia C. Mouthwash use and oral cancer risk: quantitative meta-analysis of epidemiologic studies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(6):e130.