Does LISTERINE® Work? A Study of Efficacy


Determine the efficacy of a mouthrinse used as a supplement to regular oral hygiene measures on supragingival dental plaque and gingivitis (N=107).


Double-blind, controlled clinical study of healthy male and female subjects (aged 18-60 years) with preexisting plaque and gingivitis but without evidence of periodontitis.



LISTERINE® Antiseptic inhibited the accumulation of supragingival dental plaque by 34.4% (P<0.001) and the development of gingivitis by 33.7% (P<0.001) at 6 months compared to hydroalcohol control.



When used as a supplement to normal oral hygiene following a prophylaxis, LISTERINE®Antiseptic significantly reduced plaque and gingivitis over a 6-month period, without an increase in extrinsic tooth stain.

†Subjects followed their usual oral hygiene and dietary habits.

Reference: 1. DePaola LG, Overholser CD, Meiller TF, Minah GE, Niehaus C. Chemotherapeutic inhibition of supragingival dental plaque and gingivitis development. J Clin Periodontol. 1989;16:311-315.